- Title
- Hemoglobin A1C is independently associated with severity and prognosis of brainstem infarctions
- Creator
- Li, Haiyan; Kang, Zhuang; Qiu, Wei; Hu, Biao; Wu, Ai-Min; Dai, Yongqiang; Hu, Xueqiang; Luo, Jesse; Zhang, Bingjun; Lu, Zhengqi
- Relation
- Journal of the Neurological Sciences Vol. 317, Issue 1-2, p. 87-91
- Publisher Link
- http://dx.doi.org/10.1016/j.jns.2012.02.024
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2012
- Description
- Objective: To assess the association of Hemoglobin A1C (HbA1c) with acute brainstem infarctions (BSIs) and to determine whether HbA1c is an independent risk factor in BSIs patients. Methods: 96 only BSIs patients were categorized into four groups according to HbA1c as < 6%, ≥ 6% but < 7%, ≥ 7% but < 8%, or ≥ 8%, respectively. The association of the four HbA1c groups with diffusion-weighted imaging (DWI) infarct volumes (DIV), National Institutes of Health Stroke Scale (NIHSS), and follow-up modified Rankin Scale (FmRS) scores were analyzed. Patients also were categorized into two groups according to HbA1c < 6% or ≥ 6%. Logistic regression analyses were performed to determine independent risk factors. Results: There was a significant correlation between HbA1c and DIV (Spearman ρ = 0.339, P = 0.001), NIHSS scores (ρ = 0.292, P = 0.004) and FmRS scores (ρ = 0.315, P = 0.002). The incidence of pons infarction was highest in BSIs and patients with HbA1c ≥ 6% showed significantly more frequent isolated pontine infarction. Logistic regression analyses showed that only HbA1c was independently associated with larger DIV (P = 0.025) and FmRS scores (P = 0.026). Conclusions: These results suggest that elevated HbA1c level may be a potential serologic marker in the evaluation of the severity and prognosis of acute BSIs. There is an urgent need to study control of diabetes mellitus (DM) before and after BSIs.
- Subject
- brainstem infarctions; hemoglobin A1C; prognosis; severity
- Identifier
- http://hdl.handle.net/1959.13/1327598
- Identifier
- uon:25698
- Identifier
- ISSN:0022-510X
- Language
- eng
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